OGUNLADE, OLADIPUPO OLAWUMI and Covenant University, Theses (2018) EFFECT OF HYDRO-ETHANOLIC EXTRACT OF Laportea aestuans ON BENIGN PROSTATIC HYPERPLASIA. Masters thesis, COVENANT UNIVERSITY.
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Abstract
Several plants have been used in ancient times as medicines to treat, manage and prevent many diseases in various traditional settings throughout the world. The effect of administration of hydroethanolic extract of Laportea aestuans (La) leaves at different doses in Wistar rats induced with benign prostatic hyperplasia (BPH) was studied using antioxidant parameters, prostate specific antigen (PSA), relative prostate weight and phytochemical screening. Thirty (30) animals were randomly divided into six (6) groups (A-F) of five (5) animals each. BPH was induced in the animals by daily subcutaneous injection of testosterone propionate (TP) (3mg/kg) in olive oil and administration of treatments for four (4) weeks were done concurrently. Group A received olive oil alone subcutaneously, group B was induced with BPH alone, groups C-E were induced with BPH but received different doses of La at 100, 200 and 400mg/kg. Lastly, group F was induced with BPH but treated with finasteride (5mg/kg) which serves as the positive control group. Phytochemical screening results shows that saponins, flavonoids (0.5010±0.0009mg/ml), alkaloids (0.528mg/ml), phenols (0.6195±0.0015mg/ml), tannins (0.5410±0.0013mg/ml) and steroids (1.6230±0.0210 mg/ml) were present in hydro-ethanolic extract of La. The relative prostate weight result decreased significantly (p<0.05) in the 400mg/kg La (1.15± 0.14mg) in comparison to the BPH group (1.58±0.05mg). PSA level also decreased significantly (p<0.05) in the 400mg/kg La (131±1.91pg/ml) when compared to the BPH group (174±4.13pg/ml). Meanwhile, the levels of SOD, CAT and GSH increased significantly (p<0.05) at 400mg/kg La (48.1±4.17U/mg protein), (29.43±1.38U/mg protein) and (30.60±2.05ug/ml) respectively when compared to the BPH group (35.5±0.97U/mg protein), (11.36±2.39U/mg protein) and (15.60±1.14ug/ml). Antioxidant, PSA and relative prostate weight results may be due to the phytochemicals present in the plant. These findings also indicate that Laportea aestuans could be useful in the management of benign prostatic hyperplasia.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | aestuans, benign prostatic hyperplasia, prostate specific antigen, antioxidant, phytochemicals |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Chemistry |
| Depositing User: | Mrs Hannah Akinwumi |
| Date Deposited: | 13 Aug 2020 16:46 |
| Last Modified: | 13 Aug 2020 16:46 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/13525 |
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