OBODE, OKUKWE CHRISTA and Adebayo, H. A. and Omonhinmin, Conrad A. and Yakubu, Omolara Faith (2020) A systematic review of medicinal plants used in Nigeria for hypertension management. International Journal of Pharmaceutical Research, 12 (4). pp. 1-46.
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Abstract
Hypertension is a major health challenge in Nigeria and indeed worldwide. Managing hypertension is a huge burden as most persons living with the condition are either undiagnosed or undertreated due to poor health care or financial constraints. Although conventional antihypertensive drugs are available, the disease is still poorly managed. In Nigeria, herbal plants have played a major role in the management of diseases including hypertension. In this study, 136 medicinal plants used for hypertension management across the various ethnic communities in Nigeria which were accessed in open data sources until July 2018 were reported and presented systematically looking closely at their mechanism(s) of action. Analyses showed that the report was skewed towards the South-West, South-East and the North East of Nigeria and plants were mostly reported from communities in Sokoto and Edo states. Plants of the families of Fabaceae, Malvaceae, Apocynaceae and Euphorbiaceae were commonly used. Preliminary phytochemical evaluations revealed that 89.71% contained phenolic compounds, while 64.71 and 39.71% showed alkaloids and terpenes respectively. Plants whose antihypertensive mechanisms of action were reported, elicited either angiotensin-converting enzyme inhibition, diuretic effect, increased nitric oxide production, radical scavenging potentials, calcium channel blocking effects, decreased proliferation of the vascular smooth muscle cells, enhanced vasodilation, direct blood pressure lowering effects, renin inhibition or anti-inflammatory properties. It is hoped that this review will provide useful information to relevant institutions such as pharmaceutical industries, governmental agencies and most importantly the scientific community as this will serve as a guide that will lead to the discovery of new leads for hypertension management.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Nigeria, hypertension, phytochemicals, medicinal plants, ethnobotanical use |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
| Depositing User: | AKINWUMI |
| Date Deposited: | 10 Feb 2023 10:17 |
| Last Modified: | 10 Feb 2023 10:17 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/16598 |
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