Early-life AFB1 exposure: DNA methylation and hormone alterations.

Rotimi, Oluwakemi A and De Campos, Opeyemi Christianah and Adelani, Isaacson Bababode and Olawole, Tolulope Dorcas and Rotimi, S. O (2023) Early-life AFB1 exposure: DNA methylation and hormone alterations. Vitam Horm, 1 (22). pp. 237-252.

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Abstract

Aflatoxins are secondary metabolites of mold that contaminate food and feedstuff. They are found in various food including grains, nuts, milk and eggs. Aflatoxin B1 (AFB1) is the most poisonous and commonly found of the various types of aflatoxins. Exposures to AFB1 start early in life viz. in utero, during breastfeeding, and during weaning through the waning foods which are mainly grain based. Several studies have shown that early-life exposures to various contaminants may have various biological effects. In this chapter, we reviewed the effects of early-life AFB1 exposures on changes in hormone and DNA methylation. In utero AFB1 exposure results in alterations in steroid and growth hormones. Specifically, the exposure results in a reduction in testosterone levels later in life. The exposure also affects the methylation of various genes that are significant in growth, immune, inflammation, and signaling pathways.

Item Type:	Article
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User:	AKINWUMI
Date Deposited:	05 Nov 2023 20:19
Last Modified:	05 Nov 2023 20:19
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/17490

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