NNAJI, PRECIOUS CHINYERE and Covenant University, Theses Masters (2024) EXPERIMENTAL AND COMPUTATIONAL ASSESSMENT OF Discorea bulbifera DERIVED BIOCHAR AND HYDROCHAR FOR IBUPROFEN RELEASE. Masters thesis, Covenant University.
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Abstract
The efficacy of ibuprofen in inflammation management depends on efficient delivery to the targeted site. Utilising a delivery agent would involve ibuprofen adsorption and release for improved delivery. This work studies the utilisation of Discorea bulbifera derived biochar and hydrochar for ibuprofen release. The biochar was prepared in a muffle furnace at 300 oC for 90 min and the hydrochar was prepared in a hydrothermal autoclave at 200 oC for an hr. Characterisation of the chars was performed using several techniques such as Brunauer-Emmett-Teller (BET) analysis, Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (XRD), electron dispersive X-ray (EDX), and scanning electron microscopy (SEM). The following biochemical assays were carried out; Protein albumin denaturation assay, hypotonic solution induced hemolysis stabilizing assay, Heat induced hemolysis stabilizing assay. Ibuprofen equilibrium adsorption was performed at 180 min adsorption time, using concentrations (5–200 mg L−1). The equilibrium of adsorption was evaluated using the Freundlich, Temkin, and Langmuir isotherm models. Non−linear Freundlich adsorption isotherm gave the best descriptions of ibuprofen adsorptions onto the studied chars. Freundlich adsorption capacities of biochar and hydrochar are 21.977 and 19.921 mg. g−1, respectively. Egg albumin denaturation inhibition anti−inflammatory results show that biochar (≈ 85 %) performed better than hydrochar (≈ 70 %). Similar trend was observed at lower concentrations of the chars for heat induced hemolysis inhibition studies and as concentration increased, the trend changed such that hydrochar (≈ 38 %) performed better than biochar (≈ 17 %). Ibuprofen equilibrium adsorption performed using initial ibuprofen concentrations (5–200 mg L−1) was established in 2 hours, for biochar and hydrochar, and the highest ibuprofen removals occurred at pH 4. Density functional theoretical calculations gave results which are in excellent agreements with adsorption studies. Both biochar and hydrochar showed good performance as long−term adsorbents for the removal of ibuprofen and results from in vitro and computational studies indicate they have great promise for ibuprofen delivery.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Ibuprofen, Hydrochar, Biochar, Density Functional Theoretical |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Chemistry Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
| Depositing User: | nwokealisi |
| Date Deposited: | 24 Sep 2024 11:31 |
| Last Modified: | 24 Sep 2024 11:31 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/18439 |
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